E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors

E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors

Inactivating germline mutations in the <i>CDH1</i> gene (encoding the E-cadherin protein) are the genetic hallmark of hereditary diffuse gastric cancer (HDGC), and somatic <i>CDH1</i> mutations are an early event in the development of sporadic diffuse gastric cancer (DGC) and...

Full description

Bibliographic Details
Main Authors: Lyvianne Decourtye-Espiard, Nicola Bougen-Zhukov, Tanis Godwin, Tom Brew, Emily Schulpen, Michael A. Black, Parry Guilford
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
HDGC
<i>CDH1</i>
E-cadherin
HDAC inhibitors
synthetic lethality
Online Access:https://www.mdpi.com/2072-6694/14/1/175

Internet

https://www.mdpi.com/2072-6694/14/1/175

Similar Items