An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer

Abstract Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but their ability to recognize disease tissue and further achieve synergistic gene regulation has rarely been studied. Herein, Arginylglycylaspartic acid (RGD)-modified Distearyl acylphosphatidyl ethanolamine (DS...

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Bibliographic Details
Main Authors: Jiaqi Yan, Xiaodong Ma, Danna Liang, Meixin Ran, Dongdong Zheng, Xiaodong Chen, Shichong Zhou, Weijian Sun, Xian Shen, Hongbo Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42740-2