Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells

Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells

AimThe aim was to study the effect of Allitridum (Allicin) on the heterologous expression of the late sodium current on the ΔKPQ-SCN5A mutations in HEK293 cells, with a view to screening new drugs for the treatment of long QT syndrome type 3 (LQT3).Methods and ResultsThe ΔKPQ-SCN5A plasmid was trans...

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Bibliographic Details
Main Authors: Yating Chen, Yun Huang, Jing Bai, Chuanbin Liu, Shanshan Ma, Jiaxin Li, Xu Lu, Zihao Fu, Lihua Fang, Yang Li, Jiancheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
Allitridum
ΔKPQ-SCN5A mutation
HEK293 cells
late sodium current
LQT3
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.636485/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.636485/full

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