Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling

Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling

Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ∼1: 200–500 and predisposes individuals to heart failure and sudden death. The mechanisms through which...

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Bibliographic Details
Main Authors: Irina Zalivina, Temo Barwari, Xiaoke Yin, Sarah R. Langley, Javier Barallobre-Barreiro, Hiroko Wakimoto, Anna Zampetaki, Manuel Mayr, Metin Avkiran, Seda Eminaga
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Hypertrophic cardiomyopathy
miRNA
Fibrosis
Hypertrophy
miR-199a-3p
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976123000260

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http://www.sciencedirect.com/science/article/pii/S2772976123000260

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