Schistosome eggs stimulate reactive oxygen species production to enhance M2 macrophage differentiation and promote hepatic pathology in schistosomiasis.

Schistosome eggs stimulate reactive oxygen species production to enhance M2 macrophage differentiation and promote hepatic pathology in schistosomiasis.

Schistosomiasis is a neglected tropical disease of public health concern. The most devastating pathology in schistosomiasis japonica and mansoni is mainly attributed to the egg-induced granulomatous response and secondary fibrosis in host liver, which may lead to portal hypertension or even death of...

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Bibliographic Details
Main Authors: Yanxiong Yu, Junling Wang, Xiaohong Wang, Pan Gu, Zhigang Lei, Rui Tang, Chuan Wei, Lei Xu, Chun Wang, Ying Chen, Yanan Pu, Xin Qi, Beibei Yu, Xiaojun Chen, Jifeng Zhu, Yalin Li, Zhijie Zhang, Sha Zhou, Chuan Su
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0009696

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https://doi.org/10.1371/journal.pntd.0009696

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