The Yin and Yang-Like Clinical Implications of the <i>CDKN2A/ARF/CDKN2B</i> Gene Cluster in Acute Lymphoblastic Leukemia

The Yin and Yang-Like Clinical Implications of the <i>CDKN2A/ARF/CDKN2B</i> Gene Cluster in Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a malignant clonal expansion of lymphoid hematopoietic precursors that exhibit developmental arrest at varying stages of differentiation. Similar to what occurs in solid cancers, transformation of normal hematopoietic precursors is governed by a multistep oncoge...

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Bibliographic Details
Main Authors: Celia González-Gil, Jordi Ribera, Josep Maria Ribera, Eulàlia Genescà
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Genes
Subjects:
acute lymphoblastic leukemia
del(9p21.3)
prognosis
leukemogenesis
treatment
Online Access:https://www.mdpi.com/2073-4425/12/1/79

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https://www.mdpi.com/2073-4425/12/1/79

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