Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.

Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.

Alport disease in humans, which usually results in proteinuria and kidney failure, is caused by mutations to the COL4A3, COL4A4, or COL4A5 genes, and absence of collagen α3α4α5(IV) networks found in mature kidney glomerular basement membrane (GBM). The Alport mouse harbors a deletion of the Col4a3 g...

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Bibliographic Details
Main Authors: Brooke M Steenhard, Roberto Vanacore, David Friedman, Adrian Zelenchuk, Larysa Stroganova, Kathryn Isom, Patricia L St John, Billy G Hudson, Dale R Abrahamson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3517557?pdf=render

Internet

http://europepmc.org/articles/PMC3517557?pdf=render

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