BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cutaneous squamous cell carcinoma (cSCC) during ther...

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Bibliographic Details
Main Authors: Harina Vin, Sandra S Ojeda, Grace Ching, Marco L Leung, Vida Chitsazzadeh, David W Dwyer, Charles H Adelmann, Monica Restrepo, Kristen N Richards, Larissa R Stewart, Lili Du, Scarlett B Ferguson, Deepavali Chakravarti, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L Curry, Kevin B Kim, Ana M Ciurea, Madeleine Duvic, Victor G Prieto, Stephen E Ullrich, Kevin N Dalby, Elsa R Flores, Kenneth Y Tsai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-11-01
Series:eLife
Subjects:
protein kinase
cancer
apoptosis
melanoma
squamous cell carcinoma
targeted therapy
Online Access:https://elifesciences.org/articles/00969

Internet

https://elifesciences.org/articles/00969

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