The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway

The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway

ABSTRACT The insect immune deficiency (IMD) pathway is a defense mechanism that senses and responds to Gram-negative bacteria. Ticks lack genes encoding upstream components that initiate the IMD pathway. Despite this deficiency, core signaling molecules are present and functionally restrict tick-bor...

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Bibliographic Details
Main Authors: Lindsay C. Sidak-Loftis, Kristin L. Rosche, Natasha Pence, Jessica K. Ujczo, Joanna Hurtado, Elis A. Fisk, Alan G. Goodman, Susan M. Noh, John W. Peters, Dana K. Shaw
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
Ixodes scapularis
immune deficiency pathway
unfolded-protein response
Borrelia burgdorferi
Anaplasma phagocytophilum
tick-borne disease
Online Access:https://journals.asm.org/doi/10.1128/mbio.00703-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00703-22

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