Insulin Glargine and Insulin Aspart Overdose With Pharmacokinetic Analysis

ABSTRACT: Objective: Insulin glargine is a long-acting insulin analogue with biotransformation, at the injection site, to a primary active metabolite (glargine-M1). Combined therapy with rapid-acting insulin aspart is common, but pharmacokinetics with supra-therapeutic doses have not been reported....

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Bibliographic Details
Main Authors: Christian C.K. Kim, MD, Thomas G. Rosano, PhD, Erin E. Chambers, PhD, Manjunath P. Pai, PharmD, James Desemone, MD
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:AACE Clinical Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2376060520302923