Identification of Agents That Ameliorate Hyperphosphatemia-Suppressed Myogenin Expression Involved in the Nrf2/p62 Pathway in C2C12 Skeletal Muscle Cells

Identification of Agents That Ameliorate Hyperphosphatemia-Suppressed Myogenin Expression Involved in the Nrf2/p62 Pathway in C2C12 Skeletal Muscle Cells

Hyperphosphatemia can occur as a result of reduced phosphate (P<sub>i</sub>) excretion in cases of kidney dysfunction, which can induce muscle wasting and suppress myogenic differentiation. Higher P<sub>i</sub> suppresses myogenic differentiation and promotes muscle atrophy t...

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Bibliographic Details
Main Authors: Shu-Man Hsieh Li, Shu-Ting Liu, Yung-Lung Chang, Gunng-Shinng Chen, Shih-Ming Huang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
hyperphosphatemia
myogenin
nuclear factor erythroid 2-related factor 2
p62
L-ascorbic acid
Online Access:https://www.mdpi.com/1422-0067/23/23/15324

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https://www.mdpi.com/1422-0067/23/23/15324

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