Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism

Abstract Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individual endosomes, emphasising an autonomous and stocha...

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Bibliographic Details
Main Authors: Harrison M. York, Kunaal Joshi, Charles S. Wright, Laura Z. Kreplin, Samuel J. Rodgers, Ullhas K. Moorthi, Hetvi Gandhi, Abhishek Patil, Christina A. Mitchell, Srividya Iyer-Biswas, Senthil Arumugam
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40428-1