Genetic variation in salt taste receptors impact salt intake and blood pressure
Abstract So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors’ genes with dietary salt intake and blood pressure. A...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23827-0 |
| _version_ | 1797864955513405440 |
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| author | Noushin Mohammadifard Faezeh Moazeni Fatemeh Azizian-Farsani Mojgan Gharipour Elham Khosravi Ladan Sadeghian Asieh Mansouri Shahin Shirani Nizal Sarrafzadegan |
| author_facet | Noushin Mohammadifard Faezeh Moazeni Fatemeh Azizian-Farsani Mojgan Gharipour Elham Khosravi Ladan Sadeghian Asieh Mansouri Shahin Shirani Nizal Sarrafzadegan |
| author_sort | Noushin Mohammadifard |
| collection | DOAJ |
| description | Abstract So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors’ genes with dietary salt intake and blood pressure. A cross-sectional study was carried out among 116 randomly selected healthy adults aged ≥ 18 in Isfahan, Iran. Participants underwent sodium intake determination by 24-h urine collection, as well as dietary assessment by semi-quantitative food frequency questionnaire and blood pressure measurement. Whole blood was collected to extract DNA and genotype of SNP rs239345 in SCNN1B and rs224534, rs4790151 and rs8065080 in TRPV1 gene. Sodium consumption and diastolic blood pressure were significantly higher in carriers of the A-allele in rs239345 compared to subjects with the TT genotype (4808.4 ± 824.4 mg/day vs. 4043.5 ± 989.3 mg/day; P = 0.004) and 83.6 ± 8.5 mmHg vs. 77.3 ± 7.3 mmHg; P = 0.011), respectively. The level of sodium intake was lower in the TT genotype of TRPV1 (rs224534) than the CC genotype (3767.0 ± 713.7 mg/day vs. 4633.3 ± 793.5 mg/day; P = 0.012). We could not find any association between genotypes of all SNPs with systolic blood pressure as well as genotypes of rs224534, rs4790151 and rs8065080 with diastolic blood pressure. Genetic variations can relate with salt intake and consequently may associate with hypertension and finally cardiovascular disease risk in the Iranian population. |
| first_indexed | 2024-04-09T23:01:05Z |
| format | Article |
| id | doaj.art-b830a1f3c0aa416ab9bcdb5b7e2da3e1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:01:05Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b830a1f3c0aa416ab9bcdb5b7e2da3e12023-03-22T10:59:58ZengNature PortfolioScientific Reports2045-23222023-03-011311810.1038/s41598-022-23827-0Genetic variation in salt taste receptors impact salt intake and blood pressureNoushin Mohammadifard0Faezeh Moazeni1Fatemeh Azizian-Farsani2Mojgan Gharipour3Elham Khosravi4Ladan Sadeghian5Asieh Mansouri6Shahin Shirani7Nizal Sarrafzadegan8Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesDepartment of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical SciencesInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesPerdiatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesHypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesDepartment of Cardiology, Tehran University of Medical Science, Dr Ali Shariati HospitalIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical SciencesAbstract So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors’ genes with dietary salt intake and blood pressure. A cross-sectional study was carried out among 116 randomly selected healthy adults aged ≥ 18 in Isfahan, Iran. Participants underwent sodium intake determination by 24-h urine collection, as well as dietary assessment by semi-quantitative food frequency questionnaire and blood pressure measurement. Whole blood was collected to extract DNA and genotype of SNP rs239345 in SCNN1B and rs224534, rs4790151 and rs8065080 in TRPV1 gene. Sodium consumption and diastolic blood pressure were significantly higher in carriers of the A-allele in rs239345 compared to subjects with the TT genotype (4808.4 ± 824.4 mg/day vs. 4043.5 ± 989.3 mg/day; P = 0.004) and 83.6 ± 8.5 mmHg vs. 77.3 ± 7.3 mmHg; P = 0.011), respectively. The level of sodium intake was lower in the TT genotype of TRPV1 (rs224534) than the CC genotype (3767.0 ± 713.7 mg/day vs. 4633.3 ± 793.5 mg/day; P = 0.012). We could not find any association between genotypes of all SNPs with systolic blood pressure as well as genotypes of rs224534, rs4790151 and rs8065080 with diastolic blood pressure. Genetic variations can relate with salt intake and consequently may associate with hypertension and finally cardiovascular disease risk in the Iranian population.https://doi.org/10.1038/s41598-022-23827-0 |
| spellingShingle | Noushin Mohammadifard Faezeh Moazeni Fatemeh Azizian-Farsani Mojgan Gharipour Elham Khosravi Ladan Sadeghian Asieh Mansouri Shahin Shirani Nizal Sarrafzadegan Genetic variation in salt taste receptors impact salt intake and blood pressure Scientific Reports |
| title | Genetic variation in salt taste receptors impact salt intake and blood pressure |
| title_full | Genetic variation in salt taste receptors impact salt intake and blood pressure |
| title_fullStr | Genetic variation in salt taste receptors impact salt intake and blood pressure |
| title_full_unstemmed | Genetic variation in salt taste receptors impact salt intake and blood pressure |
| title_short | Genetic variation in salt taste receptors impact salt intake and blood pressure |
| title_sort | genetic variation in salt taste receptors impact salt intake and blood pressure |
| url | https://doi.org/10.1038/s41598-022-23827-0 |
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