Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats

Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats

The objective of this study was to determine the effect of eight 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-carboxyamidepyrazoles (TFDPs) on rat body temperature and baker’s yeast-induced fever. TFDPs or vehicle (5% Tween 80 in 0.9% NaCl, 5 mL/kg) were injected subcutaneously and rectal...

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Bibliographic Details
Main Authors: J.S.M. Pasin, A.P.O. Ferreira, A.L.L. Saraiva, V. Ratzlaff, R. Andrighetto, P. Machado, S. Marchesan, R.A. Zanette, H.G. Bonacorso, N. Zanatta, M.A.P. Martins, J. Ferreira, C.F. Mello
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Pyrazole derivatives
Fever
Cytokine levels
Cyclooxygenase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200009

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200009

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