Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes

Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes

Myotonic dystrophy type 1 (DM1) is characterized by debilitating neurological symptoms. Dinca et al. demonstrate the pronounced impact of DM1 on the morphology and RNA metabolism of astrocytes. Their findings suggest astroglial pathology in DM1 brain dysfunction.

Bibliographic Details
Main Authors: Diana M. Dincã, Louison Lallemant, Anchel González-Barriga, Noémie Cresto, Sandra O. Braz, Géraldine Sicot, Laure-Elise Pillet, Hélène Polvèche, Paul Magneron, Aline Huguet-Lachon, Hélène Benyamine, Cuauhtli N. Azotla-Vilchis, Luis E. Agonizantes-Juárez, Julie Tahraoui-Boris, Cécile Martinat, Oscar Hernández-Hernández, Didier Auboeuf, Nathalie Rouach, Cyril F. Bourgeois, Geneviève Gourdon, Mário Gomes-Pereira
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31594-9

Internet

https://doi.org/10.1038/s41467-022-31594-9

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