Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs. This feedback protects against cholesterol overaccumulation i...

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Bibliographic Details
Main Authors: Akash Das, Michael S Brown, Donald D Anderson, Joseph L Goldstein, Arun Radhakrishnan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-06-01
Series:eLife
Subjects:
SV-589 human fibroblast
endoplasmic reticulum
sphingomyelin
lysosome
cholesterol-phospholipid complex
Perfringolysin O
Online Access:https://elifesciences.org/articles/02882

Internet

https://elifesciences.org/articles/02882

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