Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji–Trost coupling

Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji–Trost coupling

The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported. The intramolecular allylic substitution reaction of a readily available joint urea-type substrate enables the facile preparatio...

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Bibliographic Details
Main Authors: Sebastian Bretzke, Stephan Scheeff, Felicitas Vollmeyer, Friederike Eberhagen, Frank Rominger, Dirk Menche
Format: Article
Language:English
Published: Beilstein-Institut 2016-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cross-metathesis
natural products
pyrimidines
Tsuji–Trost reaction
synthetic methods
Online Access:https://doi.org/10.3762/bjoc.12.107

Internet

https://doi.org/10.3762/bjoc.12.107

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