Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes

Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of hematologic malignancies characterized by clonal hematopoiesis, one or more cytopenias such as anemia, neutropenia, or thrombocytopenia, abnormal cellular maturation, and a high risk of progression to acute myeloid leukemia. The bone...

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Bibliographic Details
Main Authors: Amanpreet Kaur Bains, Lena Behrens Wu, Jennifer Rivière, Sandra Rother, Valentina Magno, Jens Friedrichs, Carsten Werner, Martin Bornhäuser, Katharina S. Götze, Michael Cross, Uwe Platzbecker, Manja Wobus
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
mesenchymal stromal cells
hematopoiesis
bone marrow
extracellular matrix
myelodysplastic syndromes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.961473/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.961473/full

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