Organocatalytic Asymmetric α-Chlorination of 1,3-Dicarbonyl Compounds Catalyzed by 2-Aminobenzimidazole Derivatives

Organocatalytic Asymmetric α-Chlorination of 1,3-Dicarbonyl Compounds Catalyzed by 2-Aminobenzimidazole Derivatives

Bifunctional chiral 2-aminobenzimidazole derivatives 1 and 2 catalyze the enantioselective stereodivergent α-chlorination of β-ketoesters and 1,3-diketone derivatives with up to 50% ee using N-chlorosuccinimide (NCS) or 2,3,4,4,5,6-hexachloro-2,5-cyclohexadien-1-one as electrophilic chlorine sources...

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Bibliographic Details
Main Authors: Daniel Serrano Sánchez, Alejandro Baeza, Diego A. Alonso
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Symmetry
Subjects:
organocatalysis
electrophilic chlorination
asymmetric catalysis
dicarbonyl compounds
benzimidazole
Online Access:http://www.mdpi.com/2073-8994/8/1/3

Internet

http://www.mdpi.com/2073-8994/8/1/3

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