Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy
Abstract Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeostasis. The vast majority (> 95%) of HSCs are in a resting state under physiolo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03316-5 |
| _version_ | 1797846105808961536 |
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| author | Xinyu Tang Zhenzhen Wang Jingyi Wang Siyuan Cui Ruirong Xu Yan Wang |
| author_facet | Xinyu Tang Zhenzhen Wang Jingyi Wang Siyuan Cui Ruirong Xu Yan Wang |
| author_sort | Xinyu Tang |
| collection | DOAJ |
| description | Abstract Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeostasis. The vast majority (> 95%) of HSCs are in a resting state under physiological conditions and are only activated to play a functional role under stress conditions. This resting state affects their long-term survival and is also closely related to the lifelong maintenance of hematopoietic function; however, abnormal changes may also be an important factor leading to the decline of immune function in the body and the occurrence of diseases in various systems. While the importance of resting HSCs has attracted increasing research attention, our current understanding of this topic remains insufficient, and the direction of clinical targeted treatments is unclear. Here, we describe the functions of HSCs, analyze the regulatory mechanisms that affect their resting state, and discuss the relationship between resting HSCs and different diseases, with a view to providing guidance for the future clinical implementation of related targeted treatments. |
| first_indexed | 2024-04-09T17:49:36Z |
| format | Article |
| id | doaj.art-b84238810cdd424bbab43af8e21fda21 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T17:49:36Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-b84238810cdd424bbab43af8e21fda212023-04-16T11:08:27ZengBMCStem Cell Research & Therapy1757-65122023-04-0114111810.1186/s13287-023-03316-5Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategyXinyu Tang0Zhenzhen Wang1Jingyi Wang2Siyuan Cui3Ruirong Xu4Yan Wang5Shandong University of Traditional Chinese MedicineDepartment of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineDepartment of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineDepartment of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineDepartment of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineDepartment of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineAbstract Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeostasis. The vast majority (> 95%) of HSCs are in a resting state under physiological conditions and are only activated to play a functional role under stress conditions. This resting state affects their long-term survival and is also closely related to the lifelong maintenance of hematopoietic function; however, abnormal changes may also be an important factor leading to the decline of immune function in the body and the occurrence of diseases in various systems. While the importance of resting HSCs has attracted increasing research attention, our current understanding of this topic remains insufficient, and the direction of clinical targeted treatments is unclear. Here, we describe the functions of HSCs, analyze the regulatory mechanisms that affect their resting state, and discuss the relationship between resting HSCs and different diseases, with a view to providing guidance for the future clinical implementation of related targeted treatments.https://doi.org/10.1186/s13287-023-03316-5Hematopoietic stem cellsRestingSelf-replicationDifferentiationRegulatory mechanismHemopathy |
| spellingShingle | Xinyu Tang Zhenzhen Wang Jingyi Wang Siyuan Cui Ruirong Xu Yan Wang Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy Stem Cell Research & Therapy Hematopoietic stem cells Resting Self-replication Differentiation Regulatory mechanism Hemopathy |
| title | Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy |
| title_full | Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy |
| title_fullStr | Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy |
| title_full_unstemmed | Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy |
| title_short | Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy |
| title_sort | functions and regulatory mechanisms of resting hematopoietic stem cells a promising targeted therapeutic strategy |
| topic | Hematopoietic stem cells Resting Self-replication Differentiation Regulatory mechanism Hemopathy |
| url | https://doi.org/10.1186/s13287-023-03316-5 |
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