Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particle motion within the DCM were characterized using P...

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Bibliographic Details
Main Authors: Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
dynamic colon model (DCM)
colon-specific drug formulations
magnetic resonance imaging (MRI)
positron emission tomography (PET)
in vitro models
dissolution
Online Access:https://www.mdpi.com/1999-4923/12/7/659

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https://www.mdpi.com/1999-4923/12/7/659

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