Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum

Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum

In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum. Our findings indicated that caulerpine inhibited phasic contractions induced by carbachol (IC50 = 7.0 ± 1.9 × 10−5 M), histamine (IC50 = 1.3...

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Bibliographic Details
Main Authors: Magna Suzana Alexandre-Moreira, George Emmanuel C. de Miranda, Fabiana de Andrade Cavalcante, Jéssica Celestino Ferreira Sousa, Daysianne Pereira de Lira, Bárbara Viviana de Oliveira Santos, Bagnólia Araújo da Silva, Ana Carolina de Carvalho Correia, José Maria Barbosa-Filho, Luiz Henrique Agra Cavalcante-Silva
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Marine Drugs
Subjects:
caulerpine
guinea pig ileum
spasmolytic effect
Ca2+ channel
Online Access:http://www.mdpi.com/1660-3397/11/5/1553

Internet

http://www.mdpi.com/1660-3397/11/5/1553

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