Selecting single cell clustering parameter values using subsampling-based robustness metrics

Abstract Background Generating and analysing single-cell data has become a widespread approach to examine tissue heterogeneity, and numerous algorithms exist for clustering these datasets to identify putative cell types with shared transcriptomic signatures. However, many of these clustering workflo...

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Bibliographic Details
Main Authors: Ryan B. Patterson-Cross, Ariel J. Levine, Vilas Menon
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-03957-4