<i>Staphylococcus aureus</i> Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism

<i>Staphylococcus aureus</i> Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism

Staphylococcal exfoliative toxins (ETs) are glutamyl endopeptidases that specifically cleave the Glu381-Gly382 bond in the ectodomains of desmoglein 1 (Dsg1) via complex action mechanisms. To date, four ETs have been identified in different <i>Staphylococcus aureus</i> strains and ETE is...

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Bibliographic Details
Main Authors: Carolina Gismene, Jorge Enrique Hernández González, Angela Rocio Niño Santisteban, Andrey Fabricio Ziem Nascimento, Lucas dos Santos Cunha, Fábio Rogério de Moraes, Cristiano Luis Pinto de Oliveira, Caio C. Oliveira, Paola Jocelan Scarin Provazzi, Pedro Geraldo Pascutti, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
staphylococcal exfoliative toxin E
proline flip
homodimerization
X-ray diffraction
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/17/9857

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https://www.mdpi.com/1422-0067/23/17/9857

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