Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats

Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats

Cancer chemotherapy is known to cause cognitive defects in patients. Our study investigated the effect of piracetam (PIRA; 200 or 400 mg/kg) against doxorubicin (DOX)-induced cognitive deficits in a rat model. The cognitive parameters were analyzed using elevated plus-maze, novel object recognition,...

Full description

Bibliographic Details
Main Authors: Vasudevan Mani, Syed Imam Rabbani, Ali Shariq, Palanisamy Amirthalingam, Minhajul Arfeen
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
piracetam
chemobrain
doxorubicin
acetylcholinesterase
neuroinflammation
apoptosis
Online Access:https://www.mdpi.com/1424-8247/15/12/1563

Internet

https://www.mdpi.com/1424-8247/15/12/1563

Similar Items