Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points

Summary: Innate lymphoid cells (ILCs) have been identified as potent regulators of inflammation, cell death and wound healing, which are the main biological processes involved in the progression of chronic liver disease. Obesity and chronic alcohol consumption are the leading contributors to chronic...

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Main Authors: Manon Bourinet, Rodolphe Anty, Philippe Gual, Carmelo Luci
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:JHEP Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002938
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author Manon Bourinet
Rodolphe Anty
Philippe Gual
Carmelo Luci
author_facet Manon Bourinet
Rodolphe Anty
Philippe Gual
Carmelo Luci
author_sort Manon Bourinet
collection DOAJ
description Summary: Innate lymphoid cells (ILCs) have been identified as potent regulators of inflammation, cell death and wound healing, which are the main biological processes involved in the progression of chronic liver disease. Obesity and chronic alcohol consumption are the leading contributors to chronic liver diseases in developed countries, due to inappropriate lifestyles. In particular, inflammation is a key factor in these liver abnormalities and promotes the development of more severe lesions such as fibrosis, cirrhosis and hepatocellular carcinoma. Opposite roles of ILC subsets have been described in the development of chronic liver disease, depending on the stage and aetiology of the disease. The heterogeneous family of ILCs encompasses cytotoxic natural killer cells, the cytokine-producing type 1, 2 and 3 ILCs and lymphoid tissue inducer cells. Dysfunction of these immune cells provokes uncontrolled inflammation and tissue damage, which are the basis for tumour development. In this review, we provide an overview of the recent and putative roles of ILC subsets in obesity and alcohol-associated liver diseases, which are currently the major contributors to end-stage liver complications such as fibrosis/cirrhosis and hepatocellular carcinoma.
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spelling doaj.art-b8543808d3a043568a53dd2d784c12f12024-02-08T05:13:27ZengElsevierJHEP Reports2589-55592024-02-0162100962Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey pointsManon Bourinet0Rodolphe Anty1Philippe Gual2Carmelo Luci3Université Côte d’Azur, INSERM, U1065, C3M, Nice, FranceUniversité Côte d’Azur, CHU, INSERM, U1065, C3M, Nice, FranceUniversité Côte d’Azur, INSERM, U1065, C3M, Nice, France; Corresponding authors. Address: Université Côte d’Azur, INSERM, U1065, C3M, Nice, France.Université Côte d’Azur, INSERM, U1065, C3M, Nice, France; Corresponding authors. Address: Université Côte d’Azur, INSERM, U1065, C3M, Nice, France.Summary: Innate lymphoid cells (ILCs) have been identified as potent regulators of inflammation, cell death and wound healing, which are the main biological processes involved in the progression of chronic liver disease. Obesity and chronic alcohol consumption are the leading contributors to chronic liver diseases in developed countries, due to inappropriate lifestyles. In particular, inflammation is a key factor in these liver abnormalities and promotes the development of more severe lesions such as fibrosis, cirrhosis and hepatocellular carcinoma. Opposite roles of ILC subsets have been described in the development of chronic liver disease, depending on the stage and aetiology of the disease. The heterogeneous family of ILCs encompasses cytotoxic natural killer cells, the cytokine-producing type 1, 2 and 3 ILCs and lymphoid tissue inducer cells. Dysfunction of these immune cells provokes uncontrolled inflammation and tissue damage, which are the basis for tumour development. In this review, we provide an overview of the recent and putative roles of ILC subsets in obesity and alcohol-associated liver diseases, which are currently the major contributors to end-stage liver complications such as fibrosis/cirrhosis and hepatocellular carcinoma.http://www.sciencedirect.com/science/article/pii/S2589555923002938innate lymphoid cellsMASLDALDfibrosishepatocellular carcinoma
spellingShingle Manon Bourinet
Rodolphe Anty
Philippe Gual
Carmelo Luci
Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points
JHEP Reports
innate lymphoid cells
MASLD
ALD
fibrosis
hepatocellular carcinoma
title Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points
title_full Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points
title_fullStr Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points
title_full_unstemmed Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points
title_short Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseasesKey points
title_sort roles of innate lymphoid cells in metabolic and alcohol associated liver diseaseskey points
topic innate lymphoid cells
MASLD
ALD
fibrosis
hepatocellular carcinoma
url http://www.sciencedirect.com/science/article/pii/S2589555923002938
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AT rodolpheanty rolesofinnatelymphoidcellsinmetabolicandalcoholassociatedliverdiseaseskeypoints
AT philippegual rolesofinnatelymphoidcellsinmetabolicandalcoholassociatedliverdiseaseskeypoints
AT carmeloluci rolesofinnatelymphoidcellsinmetabolicandalcoholassociatedliverdiseaseskeypoints