Protein‐Nanocaged Selenium Induces t(8;21) Leukemia Cell Differentiation via Epigenetic Regulation

Protein‐Nanocaged Selenium Induces t(8;21) Leukemia Cell Differentiation via Epigenetic Regulation

Abstract The success of arsenic in degrading PML‐RARα oncoprotein illustrates the great anti‐leukemia value of inorganics. Inspired by this, the therapeutic effect of inorganic selenium on t(8; 21) leukemia is studied, which has shown promising anti‐cancer effects on solid tumors. A leukemia‐targeti...

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Bibliographic Details
Main Authors: Long Fang, Ruofei Zhang, Lin Shi, Jiaying Xie, Long Ma, Yili Yang, Xiyun Yan, Kelong Fan
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
AML1‐ETO
oncoprotein degradation
protein nanocage
selenium nanoparticle
t(8;21) leukemia
Online Access:https://doi.org/10.1002/advs.202300698

Internet

https://doi.org/10.1002/advs.202300698

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