EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A

EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A

For the development of safe and effective EBV (Epstein-Barr virus) vaccines, the Ag85A signal peptide from M. tuberculosis H37Rv was used to construct a recombinant secretory BCG (Bacillus Chalmette-Guérin) plasmid. The Ag85A gene, fused to the EBV LMP2A (latent membrane protein) and hGM-CSF (human...

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Bibliographic Details
Main Authors: Yingchun Yan, Qing-Jie Xue, Ang Liu, Hui Wang, Honghua Zhang, Shuang Wang, Longyu Zhao, Yunqing Li, Xiuzhen Li, Yuanyuan Yang, Ting Chen, Shigen Li
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
lmp2a
hgm-csf
epstein-barr virus
cytotoxic lymphocyte
mice
Online Access:http://dx.doi.org/10.1080/21645515.2019.1670593

Internet

http://dx.doi.org/10.1080/21645515.2019.1670593

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