Evaluation of acute toxicity and in vitro antitumor activity of a novel doxorubicin-loaded folate-coated pH-sensitive liposome

Evaluation of acute toxicity and in vitro antitumor activity of a novel doxorubicin-loaded folate-coated pH-sensitive liposome

Doxorubicin (DOX) loaded liposomes have been used and studied in the last decades due to the significant decrease in DOX induced cardiac and systemic toxicity relative to administration of free drug. Therefore, new strategies are sought to improve DOX delivery and antitumor activity, while avoiding...

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Bibliographic Details
Main Authors: Juliana de Oliveira Silva, Renata Salgado Fernandes, Janaína de Alcântara Lemos, Geovanni Dantas Cassali, Adriano de Paula Sabino, Danyelle M. Townsend, Mônica Cristina Oliveira, André Luís Branco de Barros
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cytotoxicity
Doxorubicin
Folate receptor
Liposomes
Acute toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010715

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223010715

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