Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Host defense against helminth infection is mediated by mucosal type 2 immunity. Using gain- and loss-of-function mouse models, and mouse intestinal organoids, Xiong et al. show that SIRT6 modulates tuft and goblet cell expansion in intestinal epithelium by activating STAT6 to maintain type 2 mucosal...

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Bibliographic Details
Main Authors: Xiwen Xiong, Chenyan Yang, Wei-Qi He, Jiahui Yu, Yue Xin, Xinge Zhang, Rong Huang, Honghui Ma, Shaofang Xu, Zun Li, Jie Ma, Lin Xu, Qunyi Wang, Kaiqun Ren, Xiaoli S. Wu, Christopher R. Vakoc, Jiateng Zhong, Genshen Zhong, Xiaofei Zhu, Yu Song, Hai-Bin Ruan, Qingzhi Wang
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32846-4

Internet

https://doi.org/10.1038/s41467-022-32846-4

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