Positive Inotropic Effects of ATP Released via the Maxi-Anion Channel in Langendorff-Perfused Mouse Hearts Subjected to Ischemia-Reperfusion

Positive Inotropic Effects of ATP Released via the Maxi-Anion Channel in Langendorff-Perfused Mouse Hearts Subjected to Ischemia-Reperfusion

The organic anion transporter SLCO2A1 constitutes an essential core component of the ATP-conductive large-conductance anion (Maxi-Cl) channel. Our previous experiments using Langendorff-perfused mouse hearts showed that the Maxi-Cl channel contributes largely to the release of ATP into the coronary...

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Bibliographic Details
Main Authors: Hiroshi Matsuura, Akiko Kojima, Yutaka Fukushima, Yu Xie, Xinya Mi, Ravshan Z. Sabirov, Yasunobu Okada
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ATP release
endogenous ATP
ischemia-reperfusion
left ventricular contractile function
maxi-anion channel
Langendorff perfusion
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.597997/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.597997/full

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