Spinal SIRT1 activation attenuates neuropathic pain in mice.

Spinal SIRT1 activation attenuates neuropathic pain in mice.

Abnormal histone acetylation occurs during neuropathic pain through an epigenetic mechanism. Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in a variety of processes through deacetylating acetylated histone and other specific substrates. But...

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Bibliographic Details
Main Authors: Haijun Shao, Qingsheng Xue, Fujun Zhang, Yan Luo, Hao Zhu, Xiaoqing Zhang, Honghai Zhang, Wenlong Ding, Buwei Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4069177?pdf=render

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http://europepmc.org/articles/PMC4069177?pdf=render

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