Metal Ion Binding in Wild-Type and Mutated Frataxin: A Stability Study

Metal Ion Binding in Wild-Type and Mutated Frataxin: A Stability Study

This work studies the stability of wild-type frataxin and some of its variants found in cancer tissues upon Co2+ binding. Although the physiologically involved metal ion in the frataxin enzymatic activity is Fe2+, as it is customarily done, Co2+ is most often used in experiments because Fe2+ is extr...

Full description

Bibliographic Details
Main Authors: S. Morante, S. Botticelli, R. Chiaraluce, V. Consalvi, G. La Penna, L. Novak, A. Pasquo, M. Petrosino, O. Proux, G. Rossi, G. Salina, F. Stellato
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
frataxin
metal ions (Co2+)
frataxin mutants
XAS (XAFS, XANES)
termal stability
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.878017/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.878017/full

Similar Items