Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome

Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome

There is an urgent need to improve the translational validity of Alzheimer's disease (AD) mouse models. Introducing genetic background diversity in AD mouse models has been proposed as a way to increase validity and enable the discovery of previously uncharacterized genetic contributions to AD...

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Bibliographic Details
Main Authors: Cheyenne D. Hurst, Amy R. Dunn, Eric B. Dammer, Duc M. Duong, Sarah M. Shapley, Nicholas T. Seyfried, Catherine C. Kaczorowski, Erik C. B. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
mouse models
proteomics
5XFAD
B6xD2
translational
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1239116/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1239116/full

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