Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?

Abstract Amyotrophic lateral sclerosis (ALS) is characterized by adult-onset progressive degeneration of upper and lower motor neurons. Increasing numbers of genes are found to be associated with ALS; among those, the first identified gene, SOD1 coding a Cu/Zn-superoxide dismutase protein (SOD1), ha...

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Bibliographic Details
Main Authors: Yoshiaki Furukawa, Eiichi Tokuda
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Translational Neurodegeneration
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40035-020-00209-y