The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells

The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells

The most common primary central nervous system tumor in adults is glioblastoma multiforme (GBM). The high invasiveness of GBM cells is an important factor leading to inevitable tumor recurrence and a poor prognosis of patients. GNE-477, a novel PI3K/mTOR inhibitor, has been reported to exert antipro...

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Bibliographic Details
Main Authors: Yixuan Wang, Heng Shen, Qian Sun, Linyao Zhao, Hao Liu, Liguo Ye, Yang Xu, Jiayang Cai, Yuntao Li, Lun Gao, Yinqiu Tan, Baohui Liu, Qianxue Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
GNE-477
GBM
PI3K/mTOR signaling pathway
proliferation
SC79
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.659511/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.659511/full

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