Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

Abstract Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga). Using the latter, 68Ga, is preferred due to its use in positron emission tomography with...

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Bibliographic Details
Main Authors: Emma Jussing, Mélodie Ferrat, Mohammad M. Moein, Henrik Alfredéen, Tetyana Tegnebratt, Klas Bratteby, Erik Samén, Joachim Feldwisch, Renske Altena, Rimma Axelsson, Thuy A. Tran
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Human Epidermal growth factor Receptor 2
HER2-PET imaging
Gallium-68
ABY-025
Affibody
Breast cancer
Online Access:https://doi.org/10.1186/s41181-023-00226-y

Internet

https://doi.org/10.1186/s41181-023-00226-y

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