Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode <i>Litomosoides sigmodontis</i>

Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode <i>Litomosoides sigmodontis</i>

More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated infective L3 larvae reduces the worm load. This present stud...

Full description

Bibliographic Details
Main Authors:	Johanna F. Scheunemann, Frederic Risch, Julia J. Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J. Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Series:	Vaccines
Subjects:	filariae <i>Litomosoides sigmodontis</i> 3pRNA poly(I:C) vaccination nucleic acid receptor
Online Access:	https://www.mdpi.com/2076-393X/11/5/966

Similar Items

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
by: Frederic Risch, et al.
Published: (2023-06-01)

Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses
by: Laura E. Layland, et al.
Published: (2015-07-01)

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
by: Stefan J. Frohberger, et al.
Published: (2019-05-01)

ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice
by: Julia J. Reichwald, et al.
Published: (2022-06-01)

Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice
by: Karadjian Gregory, et al.
Published: (2014-01-01)

Differential tissular distribution of Litomosoides sigmodontis microfilariae between microfilaremic and amicrofilaremic mice following experimental infection
by: Bouchery T., et al.
Published: (2012-11-01)

Editorial: Host immune response and protective immune responses during filarial infections
by: Manuel Ritter, et al.
Published: (2022-12-01)

Litomosoides yutajensis n. sp., first record of this filarial genus in a mormoopid bat
by: Guerrero R., et al.
Published: (2003-09-01)

Study of types of some species of “Filaria” (Nematoda) parasites of small mammals described by von Linstow and Molin
by: Guerrero R., et al.
Published: (2011-05-01)

Examination of type material of two species of Litomosoides (Filarioidea : Onchocercidae), parasites from bats ; taxonomic consequences
by: Bain O., et al.
Published: (2003-09-01)

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
by: Alexandra Ehrens, et al.
Published: (2020-01-01)

A key to the Microfilariae of the Genus Litomosoides (Phylum Nematoda), endoparasites from Colombia bats
by: Marinkelle Cornelis J., et al.
Published: (1999-11-01)

Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.
by: Benjamin Lenz, et al.
Published: (2024-03-01)

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
by: Marc P Hübner, et al.
Published: (2020-07-01)

Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway
by: Alexandra Ehrens, et al.
Published: (2025-01-01)

The genome of Litomosoides sigmodontis illuminates the origins of Y chromosomes in filarial nematodes.
by: Lewis Stevens, et al.
Published: (2024-01-01)

Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo.
by: Juan F Quintana, et al.
Published: (2019-11-01)

Redescrição de Litomosoides brasiliensis Almeida, 1936 (Nematoda: Filariidae) Parasito de Anoura caudifera (Chiroptera: Phyllostomidae)
by: Mourão Elizabeth D, et al.
Published: (2002-01-01)

Identification and ultrastructural characterization of the Wolbachia symbiont in Litomosoides chagasfilhoi
by: Vanessa Aparecida Chagas-Moutinho, et al.
Published: (2015-02-01)

Litomosa chiropterorum Ortlepp, 1932 (Nematoda: Filarioidea) from a South African miniopterid: redescription, Wolbachia screening and phylogenetic relationships with Litomosoides
by: Junker K., et al.
Published: (2009-03-01)

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
by: Marc P Hübner, et al.
Published: (2019-01-01)

The infective larva of Litomosoides yutajensis Guerrero et al., 2003 (Nematoda: Onchocercidae), a Wolbachia-free filaria from bat
by: Guerrero R., et al.
Published: (2006-06-01)

Advances in Antiwolbachial Drug Discovery for Treatment of Parasitic Filarial Worm Infections
by: Malina A. Bakowski, et al.
Published: (2019-07-01)

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models
by: Marc P. Hübner, et al.
Published: (2020-04-01)

Filarial disease in the Brazilian Amazon and emerging opportunities for treatment and control
by: Cleudecir Siqueira Portela, et al.
Published: (2024-01-01)

A histochemical study of the Nras/let-60 activity in filarial nematodes
by: James F. Geary, et al.
Published: (2015-07-01)

Molecular mass screening of mosquitoes for filarial parasites in Germany – re-interpretation of PCR xenomonitoring results would be required
by: Aleksander Masny, et al.
Published: (2015-12-01)

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.
by: Gregory Karadjian, et al.
Published: (2017-05-01)

Molecular detection of <it>Setaria tundra </it>(Nematoda: Filarioidea) and an unidentified filarial species in mosquitoes in Germany
by: Czajka Christina, et al.
Published: (2012-01-01)

Pulmonary and Gastrointestinal Parasitic Infections in Small Ruminant Autochthonous Breeds from Centre Region of Portugal—A Cross Sectional Study
by: Maria Aires Pereira, et al.
Published: (2024-04-01)

Black flies (Diptera : Simuliidae) attracted to humans and water buffalos and natural infections with filarial larvae, probably Onchocerca sp., in northern Thailand
by: Takaoka H., et al.
Published: (2003-03-01)

Incidental detection of two adult gravid filarial worms in breast: a case report
by: Santosh Tummidi, et al.
Published: (2017-08-01)

Seasonal and diurnal biting activities and zoonotic filarial infections of two Simulium species (Diptera: Simuliidae) in northern Thailand
by: Ishii Y., et al.
Published: (2008-06-01)

Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response
by: Cécile Guth, et al.
Published: (2024-02-01)

Structural and Functional Insight into the Mechanism of <i>Bacillus subtilis</i> 6S-1 RNA Release from RNA Polymerase
by: Sweetha Ganapathy, et al.
Published: (2022-02-01)

Common parasite with uncommon associations
by: Sonal Jain, et al.
Published: (2011-03-01)

Common parasite with uncommon associations
by: Jasmita Dass, et al.
Published: (2011-01-01)

Case report: Filariasis presenting as an intra-abdominal cyst
by: Abhay K Kapoor, et al.
Published: (2011-01-01)

EXPERIMENTAL INFECTION OF RABBITS WITH Dictyocaulue filaria - PATHOLOGICAL FINDINGS
by: A. M. AL-Darraji, et al.
Published: (1990-12-01)

Assessment of coverage and compliance of mass drug administration for lymphatic filariasis in Medak District-2021
by: Tajmul Sayyad, et al.
Published: (2023-05-01)