HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses

HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses

Extramammary Paget’s disease (EMPD) is an adenocarcinoma that develops mainly in the genital region of older adults. The prognosis for advanced EMPD is almost always poor; thus, novel therapeutic strategies need to be developed. HER2-targeted antibody–drug conjugates (ADCs) such as trastuzumab emtan...

Full description

Bibliographic Details
Main Authors: Keiko Tokuchi, Takuya Maeda, Shinya Kitamura, Teruki Yanagi, Hideyuki Ujiie
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
antibody–drug conjugate
HER2
<i>ERBB2</i>
extramammary Paget’s disease
patient-derived xenograft
Online Access:https://www.mdpi.com/2072-6694/14/14/3519

Internet

https://www.mdpi.com/2072-6694/14/14/3519

Similar Items