Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesulfonamide (PTS) is a small molecule that inhibited...

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Bibliographic Details
Main Authors: Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Shih-Ping Liu, Nan-Shan Zhong, Jih-Hwa Guh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
para-toluenesulfonamide
Akt/mTOR/p70S6K pathway
lipid raft
cholesterol
castration-resistant prostate cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01223/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01223/full

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