Synergistic Combination of Facile Thiol-Maleimide Derivatization and Supramolecular Solvent-Based Microextraction for UHPLC–HRMS Analysis of Glutathione in Biofluids

Synergistic Combination of Facile Thiol-Maleimide Derivatization and Supramolecular Solvent-Based Microextraction for UHPLC–HRMS Analysis of Glutathione in Biofluids

Glutathione (GSH) is the most abundant non-protein thiol in biofluids, enabling diverse physiological functions. Among the proposed methods for GSH detection, ultra-high-performance liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry (HRMS) has the advantages of high sensiti...

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Bibliographic Details
Main Authors: Mengmeng Yan, Feng Gao, Meng Chen, Qi Hu, Yuqin Yang, Kedian Chen, Penglong Wang, Haimin Lei, Qiang Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Chemistry
Subjects:
glutathione
derivatization
supramolecular solvent
dispersive liquid–liquid microextraction
quadrupole/Orbitrap high-resolution mass spectrometry
biofluid
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.786627/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.786627/full

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