Citrate Synthase Insufficiency Leads to Specific Metabolic Adaptations in the Heart and Skeletal Muscles Upon Low-Carbohydrate Diet Feeding in Mice

Citrate Synthase Insufficiency Leads to Specific Metabolic Adaptations in the Heart and Skeletal Muscles Upon Low-Carbohydrate Diet Feeding in Mice

A decrease in TCA cycle activity may lead to impaired nutrition metabolism and cellular energy shortage. Herein, we aimed to characterize the detailed metabolic changes that compensate for energy shortages in energy-consuming organs (heart and skeletal muscles) in mice with knockout of citrate synth...

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Bibliographic Details
Main Authors: Kanako Sumi, Yuiko Hatanaka, Reina Takahashi, Naoko Wada, Chihiro Ono, Yuri Sakamoto, Hirohito Sone, Kaoruko Iida
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Nutrition
Subjects:
citrate synthase
heart
knockout mice
skeletal muscle
TCA cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.925908/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2022.925908/full

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