The Role of <i>TP53</i> in Adaptation and Evolution
The <i>TP53</i> gene is a major player in cancer formation, and it is considered the most important tumor suppressor gene. The p53 protein acts as a transcription factor, and it is involved in DNA repair, senescence, cell-cycle control, autophagy, and apoptosis. Beyond cancer, there is e...
Main Authors: | Konstantinos Voskarides, Nefeli Giannopoulou |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/3/512 |
Similar Items
-
Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo
by: Andrew M Taverner, et al.
Published: (2019-08-01) -
Neutral and adaptive explanations for an association between caste-biased gene expression and rate of sequence evolution
by: Heikki eHelanterä, et al.
Published: (2014-08-01) -
Male-benefit sexually antagonistic genotypes show elevated vulnerability to inbreeding
by: Karl Grieshop, et al.
Published: (2017-06-01) -
<i>TP53</i> Mutations as a Driver of Metastasis Signaling in Advanced Cancer Patients
by: Ritu Pandey, et al.
Published: (2021-02-01) -
Antagonistic pleiotropy and the evolution of extraordinary lifespans in eusocial organisms
by: Jan J. Kreider, et al.
Published: (2021-06-01)