MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells

MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells

Deregulation of fibroblast growth factor receptors (FGFRs) signaling, as a result of FGFR amplification, chromosomal translocation, or mutations, is involved in both initiation and progression of a wide range of human cancers. Clinical data demonstrating the dependence of cancer cells on FGFRs signa...

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Bibliographic Details
Main Authors: Kamila Kitowska, Monika Gorska-Arcisz, Dima Antoun, Izabela Zarczynska, Dominika Czaplinska, Adrian Szczepaniak, Andrzej C. Skladanowski, Maciej Wieczorek, Aleksandra Stanczak, Monika Skupinska, Rafal Sadej
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
FGFR
MET
Pyk2
acquired resistance
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.633410/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.633410/full

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