Typical response of CD14++CD16– monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis

Typical response of CD14++CD16– monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis

ObjectiveSynovitis with increased infiltration of immune cells is observed in osteoarthritis (OA). Given the inflammatory condition of synovitis, we explored the protein profile of OA synovium (OAS) and its effect on circulating monocytes activation, migration, and functional commitments.MethodsKnee...

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Bibliographic Details
Main Authors: Nik Syazana Izyan Saffery, Krishnamurithy Genasan, Chee Ken Chan, Khairul Anwar Ayob, Seow Hui Teo, Mohamed Zubair Mohamed Al-Fayyadh, Iekhsan Othman, Syafiq Asnawi Zainal Abidin, Murali Malliga Raman, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Medicine
Subjects:
osteoarthritis
synovium
inflammation
MALDI-imaging
proteomics
monocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.904721/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.904721/full

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