Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes

Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes

Adenosine synthase A (AdsA) is a key virulence factor of Staphylococcus aureus, a dangerous microbe that causes fatal diseases in humans. Together with staphylococcal nuclease, AdsA generates deoxyadenosine (dAdo) from neutrophil extracellular DNA traps thereby igniting caspase-3-dependent cell deat...

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Bibliographic Details
Main Authors: Eshraq Tantawy, Nicoletta Schwermann, Tjorven Ostermeier, Annette Garbe, Heike Bähre, Marius Vital, Volker Winstel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
Staphylococcus aureus
immune evasion
deoxyribonucleosides
deoxyguanosine
phagocyte
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.847171/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.847171/full

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