Optical Genome Mapping Helps to Identify <i>BCR::JAK2</i> Rearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review

Optical Genome Mapping Helps to Identify <i>BCR::JAK2</i> Rearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review

We report a case of myeloproliferative neoplasm, not otherwise specified (MPN-NOS)-transformed AML with <i>BCR::JAK2</i> rearrangement. Chromosomal analysis indicated a simple abnormal karyotype 46,XY,t(7;17)(q21;q24),t(9;22)(p24;q11.2). Fluorescence in situ hybridization (FISH) using a...

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Bibliographic Details
Main Authors: Neelam Vanjari, Guilin Tang, Gokce A. Toruner, Wei Wang, Beenu Thakral, Ming Zhao, Bhavana J. Dave, Joseph D. Khoury, L. Jeffrey Medeiros, Zhenya Tang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Genes
Subjects:
<i>BCR::JAK2</i> rearrangement
optical genome mapping (OGM)
complex chromosomal aberrations
myeloproliferative neoplasm (MPN)
fluorescence in situ hybridization (FISH)
Online Access:https://www.mdpi.com/2073-4425/14/12/2188

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https://www.mdpi.com/2073-4425/14/12/2188

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