CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro

CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro

Dendritic cell (DC)-based immunotherapy has increased interest among anti-cancer immunotherapies. Nevertheless, the immunosuppressive mechanisms in the tumor milieu, e.g., inhibitory immune checkpoint molecules, have been implicated in diminishing the efficacy of DC-mediated anti-tumoral immune resp...

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Bibliographic Details
Main Authors: Farid Ghorbaninezhad, Javad Masoumi, Mohammad Bakhshivand, Amir Baghbanzadeh, Ahad Mokhtarzadeh, Tohid Kazemi, Leili Aghebati-Maleki, Siamak Sandoghchian Shotorbani, Mahdi Jafarlou, Oronzo Brunetti, Mariacarmela Santarpia, Behzad Baradaran, Nicola Silvestris
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
T lymphocyte
colorectal cancer
tumor cell lysate
CTLA-4
cancer immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.931316/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.931316/full

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