Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env.

Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env.

Glycoprotein Env of human immunodeficiency virus type 1 (HIV-1) mediates viral entry through membrane fusion. Composed of gp120 and gp41 subunits arranged as a trimer-of-heterodimers, Env adopts a metastable, highly dynamic conformation on the virion surface. This structural plasticity limits the te...

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Bibliographic Details
Main Authors: Hannah M Schapiro, Mukta D Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Maria E Cilento, Michael J Root
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010531

Internet

https://doi.org/10.1371/journal.ppat.1010531

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