Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway

Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway

The homeostasis of extracellular matrix (ECM) and actin dynamics in the trabecular meshwork (TM) outflow pathway plays a critical role in intraocular pressure (IOP) regulation. We studied the role of cathepsin K (CTSK), a lysosomal cysteine protease and a potent collagenase, on ECM modulation and ac...

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Bibliographic Details
Main Authors: Avinash Soundararajan, Sachin Anil Ghag, Sai Supriya Vuda, Ting Wang, Padmanabhan Paranji Pattabiraman
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
cathepsin K
trabecular meshwork
intraocular pressure
extracellular matrix
actin cytoskeleton
Online Access:https://www.mdpi.com/2073-4409/10/11/2864

Internet

https://www.mdpi.com/2073-4409/10/11/2864

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